GGT reference ranges
| Group | Normal Range |
|---|---|
| Men | 10–71 U/L |
| Women | 6–42 U/L |
| Mild elevation | 2–3x upper limit |
| Significant elevation | >3x upper limit |
What does high GGT mean?
Causes of raised GGT
GGT is the most sensitive liver enzyme for alcohol intake, even moderate regular drinking raises GGT. Other causes include non-alcoholic fatty liver disease (NAFLD), bile duct obstruction, liver inflammation (hepatitis), certain medications (phenytoin, carbamazepine, statins), and thyroid disease. GGT alone is not diagnostic. It is always interpreted alongside ALT, AST and ALP to identify the pattern of liver disease.
GGT and alcohol
GGT is widely used as a marker of alcohol use. It rises after as little as 3–4 drinks per day and normalises within 2–6 weeks of stopping alcohol. A raised GGT with normal ALT and AST in the context of alcohol use is a common finding. If GGT is raised alongside ALT/AST, liver cell damage is more likely.
GGT with other liver tests
| Pattern | Likely cause |
|---|---|
| GGT raised, ALT/AST normal | Alcohol use, medication effect, fatty liver |
| GGT + ALT/AST raised | Hepatitis, significant liver disease |
| GGT + ALP raised | Bile duct obstruction, cholestasis |
| All liver tests raised | Significant liver disease: needs full workup |
Questions to ask your doctor
- Is my GGT elevation from alcohol or another cause?
- Do I need an ultrasound of my liver?
- Should I reduce alcohol intake and recheck?
Frequently Asked Questions
What does a raised GGT indicate?
Does alcohol affect GGT?
Can GGT be high with an otherwise normal liver?
References
The clinical information on this page is drawn from peer-reviewed sources indexed by the US National Library of Medicine. Links go to the source so you can read it yourself.
- Liver Function Tests. In: StatPearls. Treasure Island (FL): StatPearls Publishing. NCBI Bookshelf NBK482489
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