Condition Guide

Obesity

Obesity is not just a cosmetic concern. It is a complex medical condition that significantly increases the risk of diabetes, heart disease, sleep apnoea, fatty liver and several cancers.

Written by Suman Konda, PharmD, Clinical Pharmacist · Based on peer-reviewed sources · Editorial policy · Not medical advice

Last updated: · How we check our content

Understanding BMI and weight classification

BMI (kg/m²)ClassificationHealth risk
<18.5UnderweightIncreased (malnutrition)
18.5–24.9Normal weightLow
25.0–29.9OverweightMildly increased
30.0–34.9Obese (Class I)Moderately increased
35.0–39.9Obese (Class II)Severely increased
≥40Morbidly Obese (Class III)Very severely increased

Note: BMI has limitations. It does not distinguish muscle from fat. A muscular person may have a high BMI without excess fat. For Asian populations, risk thresholds are lower (overweight: BMI ≥23; obese: BMI ≥27.5).

Waist circumference: why it matters more than weight

MeasurementMenWomen
Low risk<94 cm (<37 in)<80 cm (<31.5 in)
Increased risk94–102 cm80–88 cm
High risk>102 cm (>40 in)>88 cm (>35 in)

Central obesity (excess belly fat around organs) is more metabolically dangerous than subcutaneous fat (under the skin). A high waist circumference indicates visceral fat and predicts metabolic risk better than BMI alone.

Blood tests essential in obesity

TestWhy ordered
Fasting glucose + HbA1cDiabetes / pre-diabetes: extremely common in obesity
Fasting insulin + HOMA-IRInsulin resistance (often precedes diabetes by years)
Lipid profileObesity raises triglycerides, lowers HDL, raises LDL
TSHHypothyroidism can contribute to weight gain
LFT (ALT, AST)NAFLD (fatty liver) is present in ~75% of obese patients
Uric acidObesity raises uric acid and gout risk
Vitamin DDeficiency is extremely common in obesity (stored in fat)
Sleep study (if snoring/apnoea)Sleep apnoea affects 40% of obese adults

Health conditions caused or worsened by obesity

  • Type 2 diabetes: 80% of people with T2D are overweight or obese
  • Cardiovascular disease: heart attack and stroke risk doubled
  • Hypertension: 60% of obese people have high blood pressure
  • Non-alcoholic fatty liver disease (NAFLD): 75% prevalence in obesity
  • Obstructive sleep apnoea: most cases are obesity-related
  • Osteoarthritis: each kg of weight lost reduces knee load by 4 kg
  • Cancers: breast, colon, uterine, kidney and oesophageal cancer all increased
  • PCOS: obesity worsens hormonal imbalance and insulin resistance
  • Depression and anxiety: bidirectional relationship with obesity

Questions to ask your doctor

  • What is my BMI and waist circumference?
  • Do I have pre-diabetes or insulin resistance?
  • Should I have a sleep study for sleep apnoea?
  • Am I a candidate for weight loss medication (GLP-1 agonists)?
  • Would I benefit from bariatric surgery?

References

The clinical information on this page is drawn from peer-reviewed sources indexed by the US National Library of Medicine. Links go to the source so you can read it yourself.

  1. Obesity and Comorbid Conditions. In: StatPearls. Treasure Island (FL): StatPearls Publishing. NCBI Bookshelf NBK574535

Related reading

Medical Disclaimer: This page is for general educational purposes only and does not constitute medical advice. Always consult a qualified doctor for diagnosis and treatment.